Daria Pašalić
Department of Medical Chemistry, Biochemistry and Clinical Chemistry
Zagreb University School of Medicine
Šalata ul 2.
10 000 Zagreb, Croatia
Phone +385 (1) 4590 205; +385 (1) 4566 940
E-mail: dariapasalic [at] gmail [dot] com

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P07-1 (Oral presentation)

Kušec V, Šmalcelj R. PO7-1: Vitamin D in patients on chronic dialysis treatement and kidney transplant recipients. Biochemia Medica 2009;19(Suppl 1):S135-S136.
Clinical Institute for Laboratory Diagnostics, Zagreb Clinical Hospital Centre, Zagreb, Croatia
Corresponding author:vkusec [at] kbc-zagreb [dot] hr
Introduction: Disorder of mineral metabolism in chronic kidney failure results from deficient calcitriol synthesis caused by hyperphosphatemia and kidney tissue loss. 25-OHD synthesis in the liver is not affected, its deficiency is a consequence of life style in sickness, and delays normalisation of mineral metabolism after kidney transplantation. The aim of this investigation was assessment of vitamin D status by measurement of 25-OHD in 101 patient on chronic dialysis (CD, 53 M, 48 F) and in 441 kidney transplant recipients (KT, 250 M, 191 F).
Methods: 25-OHD was measured by ELISA kit (IDS, UK).
Results: In CD patients no difference in 25-OHD between sexes existed, and deficiency (< 75 nmol/L) was present in 76% (77/101, 35.2 ± 17.7). In the remaining 24 patients 25-OH D was 118.8 ± 49.4 (75-295). Significantly lower (P < 0.001) 25-OHD in the winter period (October/March; 27.9 ± 16.1, N = 9) than in summer (April/September; 57.7 ± 46.7, N = 92) was considered relative due to small sample. In KT patients 25-OHD was lower in women (45.9 ± 26.3; P < 0.005) than in men (60.7 ± 38.0), but no difference existed during the year. Deficiency was found in 77% (340/441) KT patients, and in the remaining 101 was 101.9 ± 31.8 (75-262). No difference between sexes was found. In the entire group 25-OHD deficiency was present in 71% men (216/304) and 84% women (201/239). Vitamin D deficiency was found in > 75% patients, without difference regarding diagnosis. In women deficiency was more frequent and after kidney transplantation 25-OHD was less than in men. The seasons did not influence 25-OHD.

Conclusion: Large proportion of 25-OHD deficiency in women is a negative risk factor for osteoporosis and mineral metabolism disorder.