Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: ©Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2022, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 28 June 2021
Date accepted: 22 December 2021
Publication date (print and electronic): 15 February 2022
Volume: 32
Issue: 1
Electronic Location Identifier: 010706
Publisher ID: bm-32-1-010706
DOI: 10.11613/BM.2022.010706
Dynamic profiles and predictive values of some biochemical and haematological quantities in COVID-19 inpatients
Laura García-Tejada[1]
Ariadna Arbiol-Roca[1]
Lourdes Sánchez-Navarro[2]
Loreto Rapún-Mas[1]
Isabel Cachon-Suárez[1]
Marta Álvarez-Álvarez[1]
Dolors Dot-Bach[1]
Roser Güell-Miró[2]
Anna Cortés-Bosch de Bassea[2]
Macarena Dastis-Arias[1]
Ana Sancho-Cerro[2]
Noelia Díaz-Troyano[1]
Teresa Escartín-Diez[1]
Diego Muñoz-Provencio[1]
Rosa Navarro-Badal[1]
Author notes:
[*] Corresponding author: mjcastro@bellvitgehospital.cat
Introduction
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in some hospitalized patients has shown some important alterations in laboratory tests. The aim of this study was to establish the most relevant quantities associated with the worst prognosis related to COVID-19.
Materials and methods
This was a descriptive, longitudinal, observational and retrospective study, in a cohort of 845 adult inpatients from Bellvitge University Hospital (L’Hospitalet de Llobregat, Barcelona, Spain). A multivariate regression analysis was carried out in demographic, clinical and laboratory data, comparing survivors (SURV) and non-survivors (no-SURV). A receiver operating characteristic analysis was also carried out to establish the cut-off point for poor prognostic with better specificity and sensibility. Dynamic changes in clinical laboratory measurements were tracked from day 1 to day 28 after the onset of symptoms.
Results
During their hospital stay, 18% of the patients died. Age, kidney disease, creatinine (CREA), lactate-dehydrogenase (LD), C-reactive-protein (CRP) and lymphocyte (LYM) concentration showed the strongest independent associations with the risk of death in the multivariate regression analysis. Established cut-off values for poor prognosis for CREA, LD, CRP and LYM concentrations were 75.0 μmol /L, 320 U/L, 80.9 mg/L and 0.69 x109/L. Dynamic profile of laboratory findings, were in agreement with the consequences of organ damage and tissue destruction.
Conclusions
Age, kidney disease, CREA, LD, CRP and LYM concentrations in COVID-19 patients from the southern region of Catalonia provide important information for their prognosis. Measurement of LD has demonstrated to be very good indicator of poor prognosis at initial evaluation because of its stability over time.
Keywords: COVID-19; pneumonia; prognosis; SARS-CoV-2
