Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: ©Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2023, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 17 October 2023
Date accepted: 06 May 2024
Publication date: 05 August 2024
Publication date: 15 October 2024
Volume: 34
Issue: 3
Electronic Location Identifier: 030701
Publisher ID: bm-34-3-030701
DOI: 10.11613/BM.2024.030701
Serum concentration of ferroportin in women of reproductive age
Lada Rumora[3]
Nikolina Penava[4]
Vajdana Tomić[4]
[1] Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina
[2] School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina
[3] Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
[4] Department of Obstetrics and Gynecology, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina
Author notes:
[*] Corresponding author: anna.cuk90@gmail.com
Author contributions
A Ćuk: Conceptualization, Methodology, Writing - review & editing. L. Rumora, I. Mikulić: Investigation, Visualization, Writing - original draft. N. Penava, V. Tomić: Investigation. I. Cvetković, A. Pušić, V. Mikulić, K. Ljubić: Formal analysis, Investigation.
• Serum concentration of ferroportin in 100 women of reproductive age
• Serum ferroportin concentration in relation to ferritin concentration and recommended reference interval for ferroportin for women of reproductive age
• Ferroportin might become a potentially useful parameter in clinical states associated with disturbed iron homeostasis
Introduction
Ferroportin (Fpn) is the only known iron exporter and plays an essential role in iron homeostasis. Serum concentrations of Fpn in health and/or diseased states are still mostly unknown. Therefore, the aim of this study was to determine the concentration of Fpn in the serum of women of reproductive age (WRA) for the first time, and to establish whether there is a difference in the concentration of Fpn according to ferritin status.
Materials and methods
This research included 100 WRA (18-45 years, C-reactive protein (CRP) < 5 mg/L, hemoglobin > 120 g/L). Serum Fpn was measured using Enzyme Linked Immunosorbent Assay (ELISA) method on the analyzer EZ Read 800 Plus (Biochrom, Cambridge, UK). Reference interval was calculated using the robust method.
Results
The median concentration of Fpn in the whole study group was 9.74 (5.84-15.69) µg/L. The subgroup with ferritin concentration > 15 µg/L had a median Fpn concentration 15.21 (10.34-21.93) µg/L, which significantly differed from Fpn concentration in the subgroup with ferritin concentration ≤ 15 µg/L (5.93 (4.84-8.36) µg/L, P < 0.001). The reference limits for the Fpn were 2.26-29.81 µg/L with 90% confidence intervals (CI) of 1.78 to 2.83 and 25.37 to 34.33, respectively.
Keywords: ferroportin; ferritin; iron; reference interval
