Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2018, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 14 September 2017
Date accepted: 28 November 2017
Publication date (electronic): 10 January 2018
Publication date (print): 15 February 2018
Volume: 28
Issue: 1
Electronic Location Identifier: 010904
Publisher ID: bm-28-1-010904
DOI: 10.11613/BM.2018.010904
Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study
Serena Tessarolo[1]
Paola Giubbilini[1]
Paola Gaia[1]
Samantha D. Corino[1]
Sarah Mazza[1]
Roberta Rigolini[1]
Marco Dei Poli[2]
Elena Vianello[3]
Elena Costa[1]
[1] Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
[2] Intensive Care Unit, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
[3] Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
Author notes:
[*] Corresponding author: benedetta.rampoldi@grupposandonato.it
Introduction
Acute kidney injury (AKI) occurs frequently after abdominal aortic surgery and there is currently no effective marker able to detect early onset. The aim of this study is to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) to early identify the development of acute renal damage in patients undergoing endovascular aneurysm repair (EVAR) or open aortic repair (OAR).
Materials and methods
Serial samples of blood and urine were obtained from 25 patients undergoing both EVAR and OAR. Seven male subjects with AKI and 18 subjects with no-AKI (17 males, 1 female) were included in the study. We determined concentrations of serum creatinine (sCr) and urinary, serum and whole blood NGAL (uNGAL, sNGAL, bNGAL) collected at baseline, and after 4 and 18 hours. AKI was defined according to the RIFLE criteria (risk, injury, failure, loss of kidney function, and end-stage kidney disease): increase by 50% in sCr or reduction of at least 25% of estimated glomerular filtration rate (eGFR) from baseline.
Results
Seven patients developed AKI in the stage Risk. There was no significant difference in sNGAL concentrations in the AKI group as compared to no-AKI group. However, the uNGAL/uCreatinine ratio and bNGAL concentrations were significantly higher after 18 hours in the AKI group (no-AKI 1.69 (0.91 - 2.47) vs AKI 3.2 (2.08 - 5.92) ng/mg for uNGAL/uCreatinine ratio, P = 0.036; and no-AKI 83 (59 - 131) vs AKI 164 (126 – 263) ng/mL for bNGAL, P = 0.029).
Keywords: acute kidney injury; neutrophil gelatinase-associated lipocalin; cardiovascular surgery; early detection; urinary biomarkers
