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Routine data analysis for moderate hemolysis interference correction in neuron specific enolase quantification

Leyre Ruiz, Tomás Munoz, Alvaro González, Estibaliz Alegre

Short communications, Volume 35, June, Issue 2

KEYWORDS: NSE; hemolysis; interference; correction formula

https://doi.org/10.11613/BM.2025.020802

Application and insights on patient-based real-time quality control: detecting undetected errors in internal quality control through daily antibody positivity rate analysis

Chaochao Ma, Qi Zhang, Yingying Hu, Wenyi Ding, Liangyu Xia, Ling Qiu

Short communications, Volume 35, June, Issue 2

KEYWORDS: Patient-Based Real-Time Quality Control; daily positivity rate; thyroid peroxidase antibody; systematic error; quality assessment

https://doi.org/10.11613/BM.2025.020801

Glucose inhibitor tubes in Croatian laboratories: are we doing well?

Alen Vrtarić, Nora Nikolac Gabaj, Ivana Ćelap

Short communications, Volume 34, October, Issue 3

KEYWORDS: preanalytical phase; glucose; glucose inhibitor; anticoagulants; citrate

https://doi.org/10.11613/BM.2024.030901

Short- and long-term stability of synovial fluid calprotectin

Helena Čičak, Stjepan Bulat, Joško Jeličić, Alan Ivković, Ksenija Maštrović Radončić, Vanja Radišić Biljak, Lora Dukić, Ana-Maria Šimundić

Original articles, Volume 34, October, Issue 3

KEYWORDS: calprotectin; preanalytical phase; stability; synovial fluid

https://doi.org/10.11613/BM.2024.030704

The band count imprecision – a Croatian multicentric pilot study

Vanja Radišić Biljak, Višnja Jureša, Valentina Vidranski, Ivana Vuga, Franciska Tomić, Fran Smaić, Martina Horvat, Branka Krešić, Brankica Šimac, Ivana Lapić

Short communications, Volume 34, June, Issue 2

KEYWORDS: neutrophils; observer variation; hematology

https://doi.org/10.11613/BM.2024.020803

Practical application of the patient data-based quality control method: the potassium example

Yan Zhang, Hua-Li Wang, Ye-Hong Xie, Da-Hai He, Chao-Qiong Zhou, Li-Rui Kong

Short communications, Volume 34, February, Issue 1

KEYWORDS: daily average value; patient-generated data; potassium; quality control

https://doi.org/10.11613/BM.2024.010901

What did CRISPR-Cas9 accomplish in its first 10 years?

Yehya Khlidj

Short reviews, Volume 33, October, Issue 3

KEYWORDS: CRISPR/Cas9; deoxyribonucleases; gene editing; genetic therapy

https://doi.org/10.11613/BM.2023.030601

Diagnosis of chylous abdominal effusions: what is the triglyceride threshold value?

Bertrand Lefrère, Emmanuel Curis, Randa Bittar, Antoine Levasseur, Pierre Grès, Zoé Guilbert, Belkacem Zenati, Corinne Cherfils, Mehdi Sakka, Dominique Bonnefont-Rousselot

Short communications, Volume 33, June, Issue 2

KEYWORDS: chylous ascites; lipoprotein gel electrophoresis; triglycerides

https://doi.org/10.11613/BM.2023.020902

Higher estimated plasma volume status is associated with increased thrombotic risk and impaired survival in patients with primary myelofibrosis

Marko Lucijanic, Ivan Krecak, Ena Soric, Anica Sabljic, Davor Galusic, Hrvoje Holik, Vlatka Perisa, Martina Moric Peric, Ivan Zekanovic, Rajko Kusec

Short communications, Volume 33, June, Issue 2

KEYWORDS: cancer; cardiovascular diseases; haematology; blood plasma; prognosis

https://doi.org/10.11613/BM.2023.020901

Drug interference with biochemical laboratory tests

Jasmina Katanić, Bojan Stanimirov, Vanesa Sekeruš, Maja Đanić, Nebojša Pavlović, Momir Mikov, Karmen Stankov

Short review, Volume 33, June, Issue 2

KEYWORDS: biochemical marker; clinical laboratory test; diagnostic error; drug-laboratory test interaction; pharmaceuticals

https://doi.org/10.11613/BM.2023.020601

Underfilled blood tube containing EDTA: Is it an inappropriate sample for HbA1c assay?

Berrak Guven, Ismail Benice, Murat Can

Short communications, Volume 33, February, Issue 1

KEYWORDS: HbA1c; blood sample collection; preanalytical error; diabetes mellitus

https://doi.org/10.11613/BM.2023.010901

Inter-rater reliability assessment for the new-born screening quality assurance

Leonor Guiñón, Anna Soler, Rosa María López, Sonia Pajares, José Manuel González de Aledo, Ana Argudo-Ramírez, José Luis Marín, Judit García-Villoria, Ángeles Sahuquillo, Luisa Alvarez

Short communication, Volume 32, October, Issue 3

KEYWORDS: accreditation; extra-analytical phase; new-born screening; quality control

https://doi.org/10.11613/BM.2022.030901

Long pentraxin 3 as a marker of COVID-19 severity: evidences and perspectives

Roberto Assandri, Silvia Accordino, Ciro Canetta, Elisabetta Buscarini, Alessandro Scartabellati, Chiara Tolassi, Federico Serana

Short communications, Volume 32, June, Issue 2

KEYWORDS: COVID-19; inflammation; biomarkers; intensive care units

https://doi.org/10.11613/BM.2022.020901

Artificial intelligence and thyroid disease management: considerations for thyroid function tests

Damien Gruson, Pradeep Dabla, Sanja Stankovic, Evgenija Homsak, Bernard Gouget, Sergio Bernardini, Benoit Macq

Short review, Volume 32, June, Issue 2

KEYWORDS: artificial intelligence; biomarkers; clinical decision support system; digital health; thyroid diseases

https://doi.org/10.11613/BM.2022.020601

Evaluation and management of leukolysis-mediated pseudohyperkalemia in paediatric leukemic samples

Lourens Jan Peter Nonkes, Valérie de Haas, Hans Kemperman, Albert Huisman, Ruben Eduardus Antonius Musson, Wouter Marcel Tiel Groenestege

Short communications, Volume 32, February, Issue 1

KEYWORDS: leukolysis; pseudohyperkalemia; paediatric; leukocyte threshold

https://doi.org/10.11613/BM.2022.010904

Poor correlation between alcohol concentration in oral fluid and breath in subjects consuming beverages immediately before testing

Hallvard Gjerde, Anne Line Bretteville-Jensen, Håvard Furuhaugen

Short communications, Volume 32, February, Issue 1

KEYWORDS: breath tests; ethanol; feasibility studies; saliva

https://doi.org/10.11613/BM.2022.010902

Interpretative comments - need for harmonization? Results of the Croatian survey by the Working Group for Post-analytics

Vladimira Rimac, Sonja Podolar, Anja Jokic, Jelena Vlasic Tanaskovic, Lorena Honovic, Jasna Lenicek Krleza

Short communications, Volume 32, February, Issue 1

KEYWORDS: post-analytical phase; clinical laboratory; interpretative comments; questionnaire

https://doi.org/10.11613/BM.2022.010901

Estimation of inter-laboratory reference change values from external quality assessment data

Michael Paal, Katharina Habler, Michael Vogeser

Short Communications, Volume 31, October, Issue 3

KEYWORDS: reference change values; inter-laboratory; external quality assessment; measurement uncertainty; biological variation

https://doi.org/10.11613/BM.2021.030902

Seroprevalence of SARS-CoV-2 in Croatian solid-organ transplant recipients

Anna Mrzljak, Željka Jureković, Jadranka Pavičić-Šarić, Vladimir Stevanović, Irena Tabain, Željka Hruškar, Danko Mikulić, Ljubo Barbić, Tatjana Vilibić-Čavlek

Short Communications, Volume 31, October, Issue 3

KEYWORDS: COVID-19; seroprevalence; solid-organ transplant recipients; SARS-CoV-2 antibodies

https://doi.org/10.11613/BM.2021.030901

The missing slope: paradoxical shortening of activated partial thromboplastin time in a patient on unfractionated heparin therapy

Ivana Lapić, Ana Lončar Vrančić, Désirée Coen Herak, Dunja Rogić

Preanalytical Mysteries, Volume 31, June, Issue 2

KEYWORDS: pre-analytical phase; hemostasis; activated partial thromboplastin time; unfractionated heparin

https://doi.org/10.11613/BM.2021.021003

Current status of the lateral flow immunoassay for the detection of SARS-CoV-2 in nasopharyngeal swabs

Anita Somborac Bačura, Marija Dorotić, Leonarda Grošić, Monika Džimbeg, Slavica Dodig

Short Review, Volume 31, June, Issue 2

KEYWORDS: COVID-19; immunoassay; nasopharynx; SARS-CoV-2 antigen testing

https://doi.org/10.11613/BM.2021.020601

Pre-amplification as a method for improvement of quantitative RT-PCR analysis of circulating miRNAs

Ankica Sekovanić, Adrijana Dorotić, Jasna Jurasović, Daria Pašalić, Jelena Kovačić, Sandra Stasenko, Tatjana Mioč, Martina Piasek, Tatjana Orct

Short Communications, Volume 31, February, Issue 1

KEYWORDS: blood plasma; circulating microRNAs; epigenetics; pre-amplification; RT-PCR

https://doi.org/10.11613/BM.2021.010901

Women in sports: the applicability of common national reference intervals for inflammatory and coagulation biomarkers (HemSter Study)

Vanja Radišić Biljak, Valentina Vidranski, Lana Ružić, Ana-Maria Simundic, Tihomir Vidranski

Original Articles, Volume 31, February, Issue 1

KEYWORDS: sports; international physical activity questionnaire short form (IPAQ-SF); inflammation; blood coagulation; reference ranges

https://doi.org/10.11613/BM.2021.010702

Comparison of a rapid immunochromatographic test with a chemiluminescence immunoassay for detection of anti-SARS-CoV-2 IgM and IgG

Caterina Maria Gambino, Bruna Lo Sasso, Claudia Colomba, Rosaria Vincenza Giglio, Luisa Agnello, Giulia Bivona, Marcello Ciaccio

Short communication, Volume 30, October, Issue 3

KEYWORDS: COVID-19; serological test; antibodies; CLIA; immunochromatography

https://doi.org/10.11613/BM.2020.030901

Six Sigma revisited: We need evidence to include a 1.5 SD shift in the extraanalytical phase of the total testing process

Abdurrahman Coskun, Cristiano Ialongo

Short Communication, Volume 30, February, Issue 1

KEYWORDS: extraanalytical phase; shift; Sigma metric; Six Sigma; total testing process

https://doi.org/10.11613/BM.2020.010901

High-sensitivity cardiac Troponin T delta concentration after repeat pulmonary vein isolation

Ivan Zeljkovic, Sven Knecht, Florian Spies, Tobias Reichlin, Beat Schaer, Stefan Osswald, Michael Kühne, Christian Sticherling

Short communications, Volume 29, June, Issue 2

KEYWORDS: atrial fibrillation; pulmonary vein isolation; high-sensitivity troponin T; repeat procedure; recurrence

https://doi.org/10.11613/BM.2019.020902

Establishing the 99 percentile for high sensitivity cardiac troponin I in healthy blood donors from Southern Italy

Luisa Agnello, Chiara Bellia, Concetta Scazzone, Giulia Bivona, Giorgia Iacolino, Caterina Maria Gambino, Maddalena Muratore, Bruna Lo Sasso, Marcello Ciaccio

Short communications, Volume 29, June, Issue 2

KEYWORDS: troponin I; myocardial infarction; reference values; high sensitivity; 99th percentile

https://doi.org/10.11613/BM.2019.020901

A balanced scorecard for assessing a strategic plan in a clinical laboratory

Luisa Alvarez, Anna Soler, Leonor Guiñón, Aurea Mira

Short review, Volume 29, June, Issue 2

KEYWORDS: balanced scorecard; clinical laboratory; management; strategic plan

https://doi.org/10.11613/BM.2019.020601

Plasma free DNA: Evaluation of temperature-associated storage effects observed for Roche Cell-Free DNA collection tubes

Dietmar Enko, Gabriele Halwachs-Baumann, Gernot Kriegshäuser

Short Communications, Volume 29, February, Issue 1

KEYWORDS: cell-free nucleic acids; pre-analytical phase; quality improvement

https://doi.org/10.11613/BM.2019.010904

Mistaken assumptions drive new Six Sigma model off the road

Sten Westgard, Hassan Bayat, James O Westgard

Short Communications, Volume 29, February, Issue 1

KEYWORDS: Sigma metrics; Six Sigma; allowable total error

https://doi.org/10.11613/BM.2019.010903

Sigma metric revisited: True known mistakes

Abdurrahman Coskun, Mustafa Serteser, Ibrahim Ünsal

Short Communications, Volume 29, February, Issue 1

KEYWORDS: laboratory error; normal distribution; sigma metric; Six Sigma; uniform distribution

https://doi.org/10.11613/BM.2019.010902

Effects of different anticoagulants on glycated albumin quantification

Graziella Bonetti, Nicola Di Gaetano, Renata Paleari, Ferruccio Ceriotti

Short Communications, Volume 29, February, Issue 1

KEYWORDS: preanalytical phase; serum albumin; diabetes mellitus; anticoagulants

https://doi.org/10.11613/BM.2019.010901

Biotin and high-sensitivity cardiac troponin T assay

Aurélien Schrapp, François Fraissinet, Charles Hervouet, Hélène Girot, Valéry Brunel

Short Communication, Volume 28, October, Issue 3

KEYWORDS: troponin T; biotin; multiple sclerosis; preanalytical phase

https://doi.org/10.11613/BM.2018.030901

Evaluating analytical quality in clinical biochemistry laboratory using Six Sigma

Xuehui Mao, Jing Shao, Bingchang Zhang, Yong Wang

Short Communications: Special issue on Six Sigma metrics, Volume 28, June, Issue 2

KEYWORDS: Sigma metrics; total allowable error; quality control; bias

https://doi.org/10.11613/BM.2018.020904

Using Sigma metrics to establish analytical product performance requirements and optimize analytical performance of an diagnostic assay using a theoretical total PSA assay as an example

Victoria Petrides, Sharon Schneider

Short Communications: Special issue on Six Sigma metrics, Volume 28, June, Issue 2

KEYWORDS: total quality management; decision making; goals

https://doi.org/10.11613/BM.2018.020903

Comparison of Barricor™ vs. lithium heparin tubes for selected routine biochemical analytes and evaluation of post centrifugation stability

Anne Marie Dupuy, Stéphanie Badiou, Delphine Daubin, Anne Sophie Bargnoux, Chloé Magnan, Kadda Klouche, Jean Paul Cristol

Short Communications, Volume 28, June, Issue 2

KEYWORDS: blood specimen collection; plasma; test tube; evaluation

https://doi.org/10.11613/BM.2018.020902

Storage stability of commonly used haematological parameters at 33 °C

Ashish Jain, Sanchit Jain, Neha Singh, Priyanka Aswal, Shweta Pal, Sushant Kumar Meinia, Nilotpal Chowdhury

Short Communications, Volume 28, June, Issue 2

KEYWORDS: pre-analytical error; erythrocyte indices; laboratory errors; platelet count; sample stability

https://doi.org/10.11613/BM.2018.020901

Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study

Benedetta Rampoldi, Serena Tessarolo, Paola Giubbilini, Paola Gaia, Samantha D. Corino, Sarah Mazza, Roberta Rigolini, Marco Dei Poli, Elena Vianello, Massimiliano M. Corsi Romanelli, Elena Costa

Short Communications, Volume 28, February, Issue 1

KEYWORDS: acute kidney injury; neutrophil gelatinase-associated lipocalin; cardiovascular surgery; early detection; urinary biomarkers

https://doi.org/10.11613/BM.2018.010904

Upfront dilution of ferritin samples to reduce hook effect, improve turnaround time and reduce costs

Shu Juan Wu, Joshua A. Hayden

Short Communications, Volume 28, February, Issue 1

KEYWORDS: immunoassay; prozone effect; ferritin; turnaround time

https://doi.org/10.11613/BM.2018.010903

Reference intervals for six salivary cortisol measures based on the Croatian Late Adolescence Stress Study (CLASS)

Daniela Šupe-Domić, Goran Milas, Lada Stanišić, Irena Drmić Hofman, Irena Martinović Klarić

Short Communications, Volume 28, February, Issue 1

KEYWORDS: salivary cortisol; reference intervals; late adolescence

https://doi.org/10.11613/BM.2018.010902

Appropriateness of digoxin measurement in hospitalized patients

Seyma Oncu, Ayse Gelal, Ozgur Aslan, Reyhan S Ucku

Short Communications, Volume 28, February, Issue 1

KEYWORDS: digoxin; therapeutic drug monitoring; heart failure; electronic health records

https://doi.org/10.11613/BM.2018.010901

Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma

Michal Fedorko, Jaroslav Juracek, Michal Stanik, Marek Svoboda, Alexandr Poprach, Tomas Buchler, Dalibor Pacik, Jan Dolezel, Ondrej Slaby

Short communication, Volume 27, June, Issue 2

KEYWORDS: renal cell carcinoma; urine microRNAs; let-7; diagnostic biomarker

https://doi.org/10.11613/BM.2017.043

Utility of routine laboratory preoperative tests based on previous results: Time to give up

Enrique Rodríguez–Borja, Africa Corchon–Peyrallo, Gerardo Aguilar–Aguilar, Arturo Carratala–Calvo

Short Communications, Volume 27, October, Issue 3

KEYWORDS: cost-effectiveness; preoperative care; patient safety; routine diagnostic tests

https://doi.org/10.11613/BM.2017.030902

The new Greiner FC-Mix tubes equal the old Terumo ones and are useful as glucose stabilizer after prolonged storage of samples

Graziella Bonetti, Mariarosa Carta

Short Communications, Volume 27, October, Issue 3

KEYWORDS: diabetes; glucose; acidification; pre-analytical phase

https://doi.org/10.11613/BM.2017.030901

Big differences in primary care celiac disease serological markers request in Spain

Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas

Short Communication, Volume 27, February, Issue 1

KEYWORDS: celiac disease; quality indicators; clinical laboratory services; benchmarking

https://doi.org/10.11613/BM.2017.025

Stability of plasma electrolytes in Barricor and PST II tubes under different storage conditions

Luis Alfredo Bautista Balbás, Marta Segovia Amaro, Rubén Gómez Rioja, María José Alcaide Martín, Antonio Buńo Soto

Short Communication, Volume 27, February, Issue 1

KEYWORDS: specimen handling; potassium; electrolyte

https://doi.org/10.11613/BM.2017.024

Indications for laboratory tests in primary care: assessment of the most frequent indications and requests with blank clinical information

Maria Salinas, Maite López-Garrigós, Emilio Flores, Maria Leiva-Salinas, Patricia Esteban, Miguel Ahumada, Carlos Leiva-Salinas

Short communication, Volume 26, October, Issue 3

KEYWORDS: clinical laboratory; pre-analytical phase; primary care; quality indicators; test request

https://doi.org/10.11613/BM.2016.045

Additional technician tasks and turnaround time in the clinical Stat laboratory

Maria Salinas, Maite López-Garrigós, Emilio Flores, Maria Leiva-Salinas, Rosa Lillo, Carlos Leiva-Salinas

Short communication, Volume 26, June, Issue 2

KEYWORDS: medical laboratory personnel; quality indicators; health care

https://doi.org/10.11613/BM.2016.027

Haemoglobin J-Baltimore can be detected by HbA electropherogram but with underestimated HbA value

Valéry Brunel, Agnčs Lahary, Abdeslam Chagraoui, Christian Thuillez

Short communication, Volume 26, June, Issue 2

KEYWORDS: glycated haemoglobin; haemoglobin J-Baltimore; capillary electrophoresis

https://doi.org/10.11613/BM.2016.026

A case report of short-chain acyl-CoA dehydrogenase deficiency (SCADD)

Barbka Repic Lampret, Simona Murko, Marusa Debeljak, Mojca Zerjav Tansek, Petja Fister, Tadej Battelino

Case Report, Volume 25, June, Issue 2

KEYWORDS: SCAD deficiency; short chain acyl-CoA dehydrogenase deficiency; screening; acylcarnitine; polymorphism; genetic

https://doi.org/10.11613/BM.2015.029

Non-commutability of results of highly sensitive troponin I and T immunoassays

Giuseppe Lippi, Gianfranco Cervellin, Rosalia Aloe, Martina Montagnana, Gian Luca Salvagno, Gian Cesare Guidi

Short communications, Volume 22, February, Issue 1

KEYWORDS: troponin; biological markers; commutability; myocardial infarction

https://doi.org/10.11613/BM.2012.015

Cardiac troponins and physical exercise. It’s time to make a point

Giuseppe Lippi, Gianfranco Cervellin, Giuseppe Banfi, Mario Plebani

Short review, Volume 21, February, Issue 1

KEYWORDS: sports; biomarkers; acute myocardial infarction; cardiac injury; troponin

https://doi.org/10.11613/BM.2011.012

Method validation and measurement uncertainty

Višnja Gašljević

Short review, Volume 20, February, Issue 1

KEYWORDS: method validation; measurement uncertainty

https://doi.org/10.11613/BM.2010.007

Short-term increases of plasma cardiac troponin I are better evaluated by comparison with the reference change value

Giovanni Introcaso, Monica Raggi, Tiziana D’Errico, Annalisa Cavallero

Original papers, Volume 20, October, Issue 3

KEYWORDS: cardiac troponin-I; reference change value; analytical imprecision; acute coronary syndrome

https://doi.org/10.11613/BM.2010.042

Enhancing medical practice in Croatia through The Cochrane Collaboration

Livia Puljak, Dalibora Rako

Short review, Volume 19, October, Issue 3

KEYWORDS: systematic reviews; The Cochrane Collaboration; The Cochrane Library; diagnostic accuracy tests

https://doi.org/10.11613/BM.2009.024

Application of biological variation – a review

Carmen Ricós, Carmen Perich, Joana Minchinela, Virtudes Álvarez, Margarita Simón, Carmen Biosca, Mariví Doménech, Pilar Fernández, Carlos-Víctor Jiménez, José Vicente Garcia-Lario, Fernando Cava

Short review, Volume 19, October, Issue 3

KEYWORDS: biological variation; quality specifications; reference change value; delta check; laboratory report

https://doi.org/10.11613/BM.2009.023

Quality indicators

Ana-Maria Simundic, Elizabeta Topić

Short review, Volume 18, October, Issue 3

KEYWORDS: quality indicators; Total Quality Management; benchmarking; continuous improvement; accreditation; quality

https://doi.org/10.11613/BM.2008.027

Why is it necessary to recognize macroenzymes?

Ivana Čepelak, Dubravka Čvorišćec

Short review, Volume 17, June, Issue 1

KEYWORDS: macroenzymes; macro creatine kinase; immunoglobulins

https://doi.org/10.11613/BM.2007.005

Medical Laboratory Accreditation according to ISO 15189:2003. The Mexican Experience

Rosa Isabel Sierra-Amor, Maribel López-Martínez

Short review, Volume 17, December, Issue 2

KEYWORDS: accreditation; ISO 15189; medical laboratory

https://doi.org/10.11613/BM.2007.017

Obesity, lipoproteins and physical activity

Branka Salzer, Željko Trnka, Mate Sučić

Short review, Volume 16, June, Issue 1

KEYWORDS: obesity; risk factor; lipoproteins; disease prevention; physical activity

https://doi.org/10.11613/BM.2006.005

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