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Daria Pašalić
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Department of Medical Chemistry, Biochemistry and Clinical Chemistry
Zagreb University School of Medicine
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Huber A1, Pichler J1, Hefti U2, Weinberger K. PL1-1: Laboratory medicine research on highest niveau. Biochemia Medica 2011;19(Suppl1):S9.
1Kantonsspital Aarau, Aarau, Switzerland
2Kantonsspital Liestal, Liestal, Switzerland
3Biokrates Innsbruck, Innsbruck, Austria
*Corresponding author: andreas [dot] huber [at] ksa [dot] ch
 
Abstract
 
During 2 high altitude research expeditions in 2005 (Muztagh Ata, 7’627 m, Western China with 34 volunteers) and in 2009 (Pik Lenin, 7’230 m, Kirgistan with 30 volunteers) blood sampling and exercise testing was performed at different altitudes up to 6,800 m in order to gain insight into pathomechanisms of acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE). Evaluation of renal function, cardiac function und coagulation by eGFR kreat and eGFR cyst, ANP, BNP and CNP as well es various coagulation tests revealed a 30% reduction of GFR, no significant changes of cardiac markers, yet significant prothrombotic as well as hemorhagic changes of coagulation. No correlation with AMS was found, but some correlations with HACE and HAPE were seen in renal changes dependent on altitudes. Further, significant metabolic changes were detectable using mass spectrometric methods (metabolomics) indicating altitude dependent generation of reactive oxydative species (ROS). During the second expedition using a double blind study protocol, we postulated attenuation of ROS generation and improvment of exercise tolerance as well as amelioration of AMS, HACE and HAPE. Finally, the 2 expeditions allowed for an unique research activity in an exciting environment and team constellation.